The Bighorn Medicine Wheel and its surrounding landscapes on Medicine Mountain in the northern Bighorns make up one of the most important Native American sacred sites in the United States. Twenty years of compromise and conflict on how best to preserve the site involved several governmental agencies and elders representing 16 tribes.

Two battles on July 26, 1865 near Platte Bridge Station near present-day Casper, Wyo., are best understood in the context of tribal response to the Sand Creek Massacre the previous November. Twenty-eight U.S. troops were killed that day including Lt. Caspar Collins, for whom Fort Caspar and the town of Casper were later named.